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Immunosuppressive Effects of Sulfato-trans-(–)-1,2-diaminocyclohexaneplatinum(II)¹

Department of Immunotherapy, Wadley Institutes of Molecular Medicine, Dallas, Texas 75235

Sulfato-trans-(–)-1,2-diaminocyclohexane platinum(II) is a new antitumor agent. Its effect on immune responses was investigated. This agent inhibited lymphocyte transformation in response to phytohemagglutinin, pokeweed mitogen, and concanavalin A. It inhibited antibody plaque-forming spleen cells in AKR/J mice at doses ranging from 2.5 to 7.5 mg/kg i.p. It also prolonged the survival of skin grafts against major histocompatibility barriers in C57BL/6J mice transplanted with tail skin from CBA/J mice. The effective dose ranged from 2.5 to 5 mg/kg. This compound inhibited graft-versus-host reaction in three-week-old AKR/J x DBA/2JF₁ mice receiving spleen cells from AKR/J mice i.p. Significant inhibition of graft-versus-host reaction was seen with doses ranging from 1 to 7.5 mg/kg i.p. These results suggest that this drug is immunosuppressive.

¹ Supported in part by a grant from the Leland Fikes Foundation.

² To whom requests for reprints should be addressed, at Department of Immunotherapy, Wadley Institutes of Molecular Medicine, 9000 Harry Hines Blvd., Dallas, Texas 75235.

Received 3/ 1/79. Accepted 6/ 8/79.