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[Cancer Research 40, 1-12, January 1, 1980]
© 1980 American Association for Cancer Research
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An Evaluation of Chemicals and Industrial Processes Associated with Cancer in Humans Based on Human and Animal Data: IARC Monographs Volumes 1 to 201

Report of an IARC Working Group

An international ad hoc Working Group of experts in cancer research met at the International Agency for Research on Cancer (IARC) in January 1979 to evaluate the data on human and experimental animal carcinogenicity for 54 chemicals, groups of chemicals, and industrial processes. Monographs for these chemicals were published in Vols. 1 to 20 of the IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Based on evidence from human studies, 18 of the 54 chemicals or industrial processes are human carcinogens. A further 18 chemicals are probably carcinogenic for humans, although the data were considered not adequate to establish a causal association. To reflect differing degrees of evidence of carcinogenicity within this group, the chemicals were further subdivided, with 6 chemicals exhibiting a high degree of evidence and 12 chemicals exhibiting a lower degree. Data on the remaining 18 chemicals were considered insufficient to allow any evaluation of carcinogenicity. The report summarizes the background, purpose, and overall conclusions of the Working Group. The evidence supporting the evaluations is given in the "Appendix."

1 The program is supported in part by National Cancer Institute Contract NO1 CP 45608. An expanded version of this report will be published as a supplement to the IARC Monograph Series (see Ref. 6).

2 This report was prepared by Ralph Althouse, James Huff, Lorenzo Tomatis, and Julian Wilbourn, International Agency for Research on Cancer. Requests for reprints should be addressed to Dr. L. Tomatis, Chief, Unit of Chemical Carcinogenesis, IARC, 150 Cours Albert Thomas, 69372 Lyon Cedex 2, France.

3 This report results from an ad hoc Working Group which met in Lyon on January 15 to 17, 1979, to advise the Director of IARC on chemicals carcinogenic for humans. Working Group members: P. Armitage (University of Oxford, Oxford, U. K.); B. K. Armstrong, Rapporteur (University of Western Australia, Nedlands, Australia); A. L. Brown, Chairman (University of Wisconsin, Madison, Wis.); P. Bogovski (Institute of Experimental and Clinical Medicine, Tallin, U.S.S.R.); P. Cole (Harvard University, Cambridge, Mass.); N. E. Day (International Agency for Research on Cancer, Lyon, France); G. Della Porta (Istituto Nazionale per lo Studio e la Cura del Tumori, Milan, Italy); R. A. Griesemer, Rapporteur (National Cancer Institute, Bethesda, Md.); T. Hirohata (Kurume University, Kurume, Japan); W. J. Hunter (Commission of the European Communities, Luxembourg); S. D. Jayakar (Laboratorio di Genetica Biochimica ed Evoluzionistica, Pavia, Italy); L. Massé (Ecole Nationale de la Santé Publique, Rennes, France); M. C. Pike (University of Southern California Medical School, Los Angeles, Calif.); R. Preussmann (Institut für Toxikologie und Chemotherapie, Heidelberg, Federal Republic of Germany); M. A. Schneiderman (National Cancer Institute, Bethesda, Md.); L. Teppo (Finnish Cancer Registry, Helsinki, Finland); D. B. Thomas (Fred Hutchinson Cancer Research Center, Seattle, Wash.); J. K. Wagoner (Occupational Safety and Health Administration, Washington, D. C.); N. J. Wald, Vice-Chairman (University of Oxford, Oxford, U.K.); I. B. Weinstein (Columbia University, New York, N. Y).

Received 6/ 6/79. Accepted 9/18/79.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
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Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1980 by the American Association for Cancer Research.