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Transplantation of Human Malignant Mesothelioma into Nude Mice¹

Department of Neoplastic Diseases, Environmental Sciences Laboratory, and Cytogenetic Laboratory, Mount Sinai School of Medicine of the City University of New York, New York, New York 10029

Human pleural malignant mesothelioma was successfully transplanted into nude mice from 2 of 3 patients. The tumor implants of the first generation grew in 6 of 20 mice (30%), with a take of implants of 17 of 32 (53%). Overall, tumors grew from 52 of 80 mice (65%) in a total of 169 of 266 implants (64%) during the first four generations. The mean delay between transplantation and tumor growth was 46 days (range, 18 to 104 days). Pathological examination by light and electron microscopy confirmed the nature of the growing tumors in nude mice. Pathology of transplanted tumors was grossly similar to the human tumors in both first- and second-generation transplants. Up to eight generations have been presently carried out with presence of a human karyotype in transplanted tumors. The potential usefulness of this model with particular reference to chemosensitivity of these tumors will be investigated.

¹ Supported in part by USPHS Grant CA-15936 from the National Cancer Institute, NIH, and by grants from the International Association of Heat and Frost Insulators and Asbestos Workers and the Johns-Manville Corp. Presented in part at the 70th Annual Meeting of the American Association for Cancer Research, New Orleans, La., May 16 to 19, 1979 (15).

² To whom requests for reprints should be addressed.

Received 6/25/79. Accepted 10/ 5/79.

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