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Mutagenic Activity in Nipple Aspirates of Human Breast Fluid¹

Department of Epidemiology and International Health, University of California, San Francisco, California 94143

The Ames Salmonella mutagenesis test was applied to nipple aspirates of breast fluid from 456 women attending breast-screening clinics. Positive tests for presumptive mutagenic substances were found in 6.7% of the women tested. These findings support our hypothesis that mutagenic substances reach the breast epithelia and may have etiologic implications in the pathogenesis of benign disease and breast cancer.

¹ Supported in part by USPHS Grant CA 13556-08

² To whom requests for reprints should be addressed, at 1699 HSW, University of California, San Francisco, Calif. 94143.

Received 8/10/79. Accepted 9/27/79.

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