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Insignificant Tumor Bed Effect after Pretransplantation Hyperthermia¹

Department of Radiation Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114

Effect of pretransplantation hyperthermia of tumor bed on tumor growth was studied. Experimental tumors were isotransplants of a fibrosarcoma which arose spontaneously in C3Hf/Sed mice. The pretransplantation hyperthermia was given at 43.5° for 120 min by immersing the mouse foot into a constant temperature water bath. This treatment resulted in a similar foot reaction to a single -ray dose of 3500 rads, namely, complete epilation or partial moist desquamation. The pretransplantation hyperthermia failed to retard tumor growth, while the concurrent experiment on pretransplantation irradiation demonstrated marked retardation of tumor growth. No retardation was observed when tumor cells were transplanted into the contralateral untreated feet or into the untreated skin.

¹ This grant was supported in part by Grants CA13311 and CA21239 from the National Cancer Institute, Department of Health, Education, and Welfare.

² To whom requests for reprints should be addressed.

Received 6/29/79. Accepted 9/28/79.