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Relationship of Bacillus Calmette-Guérin-induced Suppressor Cells to Hematopoietic Precursor Cells¹

Departments of Medicine and Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510

Bacillus Calmette-Guérin (BCG) stimulated the proliferation of granulocyte-macrophage colony-forming cells (CFU) and activated suppressor cells that inhibit the immunization of T-lymphocytes in vitro. Increases in both CFU concentration and suppressor cell activity were moderate in the bone marrow and marked in the spleen of mice given BCG i.v. In the bone marrow, these increases were apparent 2 days after treatment with BCG, while in the spleen they did not occur until 7 days after BCG. A BCG strain that produced no increases in CFU concentration also produced no activation in suppressor cell activity. Fractionation of spleen cells through nylon wool and density gradients revealed that cell populations enriched in CFU were also enriched in suppressor cell activity. The parallelism in the response of CFU and suppressor cells to BCG indicates that there is a close relationship between these two cell populations.

¹ Supported by Grant CH-37 from the American Cancer Society and Grants CA 18341, CA 08341, and CA 09200 from the National Cancer Institute.

² Present address: Departments of Surgery and Physiology, 514 Medical Education Building, Albany Medical College of Union University, Albany, N. Y. 12208. To whom requests for reprints should be addressed.

Received 6/22/79. Accepted 10/ 9/79.

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