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A Preneoplastic Stage in the Spontaneous Neoplastic Transformation of Syrian Hamster Embryo Cells in Culture

Environmental Carcinogenesis Group, Laboratory of Pulmonary Function and Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709

Spontaneous neoplastic transformation of Syrian hamster embryo cells in culture occurs in at least two steps. An intermediate stage is represented by an aneuploid cell line which is preneoplastic. These cells differ from the diploid cells by a number of properties, including their ability to become neoplastic in vivo when injected while attached to a substrate. These results support a multistep process for neoplastic transformation of cells in vitro and caution against considering aneuploid cell lines as "normal" cells.

Received 10/ 9/79. Accepted 10/12/79.

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