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Effect of Bacillus Calmette-Guérin on the Development of Primary Lung Cancer in Syrian Golden Hamsters¹

Department of Microbiology, College of Biological Sciences [B. S. Z.], Veterinary Pathobiology [G. W. D.], and Comprehensive Cancer Center [B. S. Z.], The Ohio State University, Columbus, Ohio 43210

The effect of a single systemic or intratracheal administration of viable Mycobacterium bovis strain Bacillus Calmette-Guérin on the development of primary lung cancer in Syrian golden hamsters was assessed. M. bovis strain Bacillus Calmette-Guérin administered i.v. prior to, during, or after carcinogen treatment did not alter the incidence of lung tumors. Animals receiving intratracheal M. bovis strain Bacillus Calmette-Guérin had an increased incidence of lung tumors. Both i.v. and intratracheal routes accelerated the appearance of tumors.

¹ This investigation was supported by USPHS Grant CA 16342 from the National Cancer Institute and by IM-208 from the American Cancer Society.

² To whom requests for reprints should be addressed.

Received 1/30/80. Accepted 6/26/80.