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Failure of Pure 1-Naphthylamine to Induce Bladder Tumors in Dogs¹

Department of Pharmacology, University of Miami School of Medicine, Miami 33101, and the Pananicolau Cancer Research Institute of Miami, Miami, Florida 33136

1-Naphtylamine was administered p.o. to beagles for approximately 9 years at a daily dose of 15 mg/kg (5 days a week). At autopsy, no tumors or other pathological changes were observed in the bladders of any of these animals. With the possible exception of the excessive accumulation of lipofuscin in the hepatocytes of these dogs, no test compound-related pathological changes in other tissues of the body were observed. Analysis of the urine revealed the presence of small amounts of N-oxidation products (1-nitrosonaphthalene plus N-hydroxy-1-naphthylamine), ranging from 2.85 to 125 µg, following a dose of 1-naphthylamine. The theoretical significance of these findings is discussed.

¹ This research was supported in part by a grant from the Haskell Laboratory of the E. I. du Pont de Nemours & Co., and in part by Grant CA 14927 from the National Cancer Institute through the National Bladder Cancer Project.

² To whom requests for reprints should be addressed.

Received 8/27/79. Accepted 7/10/80.