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Bone Marrow Chromosome Abnormalities in Breast Cancer Patients following Adjuvant Chemotherapy¹

Departments of Pediatrics [S. R. P.], Internal Medicine [M. P. C.], Surgery [P. R. J.], and Pathology [F. R. D.], University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242

Two patients developed acute bone marrow cancer following mastectomy and institution of alkylating agents as adjuvant chemotherapy. An aneuploid condition was observed in both cases, along with involvement of chromosomes 11 and 12 in structural rearrangements. Subsequent studies of 18 patients who had or had not received such therapy showed no evidence of chromosomal aberrations. However, the long-term effect of adjuvant chemotherapy in cancer patients is still of concern until additional information becomes available.

¹ Supported in part by Research Grant INQ433 from the American Cancer Society.

² To whom requests for reprints should be addressed.

Received 2/19/80. Accepted 8/ 6/80.