This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Barthold, S. W. Articles by Beck, D. Search for Related Content PubMed PubMed Citation Articles by Barthold, S. W. Articles by Beck, D.

Modification or Early Dimethylhydrazine Carcinogenesis by Colonic Mucosal Hyperplasia¹

Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06510

The interaction of colonic mucosal hyperplasia with early 1,2-dimethylhydrazine (DMH) carcinogenesis was studied in random-bred NIH Swiss mice utilizing hyperplasia-inducing Citrobacter freundii. Mice inoculated with this bacterium developed significantly more DMH focal atypia than did mice without hyperplasia following a single dose of DMH (20 mg/kg). Mice with hyperplasia also developed DMH focal atypia with diminished doses of DMH (10 and 5 mg/kg), while normal mice did not. The effect of C. freundii on early DMH carcinogenesis was shown to be due to the hyperplasia rather than to a direct interaction of the bacterium with DMH. Focal atypia arose in high incidence 1 month after a single dose of DMH (20 mg/kg) but did not appear to progress to later stages of neoplasia, since significantly fewer atypia were present at 2 to 4 months among a randomized population. Colonic focal atypia may represent a reversible preneoplastic or precursor lesion as seen in other tissues, with features more aligned to neoplasia than to hyperplasia.

¹ Supported by National Large Bowel Cancer Project USPHS Research Grant CA15405 from the National Cancer Institute.

² To whom requests for reprints should be addressed.

Received 4/28/80. Accepted 8/20/80.

This article has been cited by other articles:

				D. Borenshtein, P. R. Nambiar, E. B. Groff, J. G. Fox, and D. B. Schauer Development of Fatal Colitis in FVB Mice Infected with Citrobacter rodentium Infect. Immun., July 1, 2007; 75(7): 3271 - 3281. [Abstract] [Full Text] [PDF]

				C. Brayton, M. Justice, and C. A. Montgomery Evaluating Mutant Mice: Anatomic Pathology Vet. Pathol., January 1, 2001; 38(1): 1 - 19. [Abstract] [Full Text] [PDF]

				A Konstantinidis, J. Smulow, and C Sonnenschein Tumorigenesis at a predetermined oral site after one intraperitoneal injection of N-nitroso-N-methylurea Science, June 11, 1982; 216(4551): 1235 - 1237. [Abstract] [PDF]