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Mutagenesis and Morphological Transformation of Mammalian Cells by a Non-Bay-Region Polycyclic Cyclopenta(cd)pyrene and Its 3,4-Oxide¹

Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27514 [A. G.]; Genetic Toxicology Division (MD 68), Health Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711 [S. N., M. M., H. G., G. C., B. H., D. G.]; and Department of Microbiology, Harvard School of Public Health, Boston, Massachusetts 02115 [E. E.]

Cyclopenta(cd)pyrene, a constituent of environmental emissions, has been found to mutate and transform mammalian cells in culture. Cyclopenta(cd)pyrene 3,4-oxide, a presumed metabolite, was found to be a direct-acting mutagen and to transform mammalian cells. These results suggest that cyclopenta(cd)pyrene 3,4-oxide may be an ultimate mutagenic form of the parent hydrocarbon.

¹ These studies were supported in part by Grants 1-R01-ES02021-01 and 1-R0-1-CA 28622-01 from the USPHS and Grant IN-15U from the American Cancer Society.

² To whom requests for reprints should be addressed.

Received 3/ 4/80. Accepted 8/27/80.