This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Wilson, E. L. Articles by Dowdle, E. B. Search for Related Content PubMed PubMed Citation Articles by Wilson, E. L. Articles by Dowdle, E. B.

Effects of Retinoids on Normal and Neoplastic Human Cells Cultured in Vitro

Department of Clinical Science and Immunology, University of Cape Town Medical School, Observatory 7925, Cape Town, South Africa

The effects of retinoic acid on cultured human cells derived from normal and neoplastic tissues were studied. Retinoic acid consistently induced plasminogen activator synthesis by cells of mesenchymal origin (with the exception of adult skin fibroblasts) but not by cells of epithelial origin. The effect of retinoic acid was more pronounced than that of equimolar concentrations of retinol or retinyl acetate. Dexamethasone inhibited the retinoid-induced increase in plasminogen activator in lung- and foreskin-derived fibroblasts. Cells derived from normal or neoplastic tissues showed no consistent differences either in baseline rates of plasminogen activator release or in the magnitude of the retinoid effect.

¹ To whom requests for reprints should be addressed.

Received 5/19/80. Accepted 9/15/80.