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Protective Effect of Plant Sterols against Chemically Induced Colon Tumors in Rats¹

Department of Gastroenterology, Veterans Administration Medical Center, New York, New York 10010 [R. F. R., B. I. C.]; New York University School of Medicine [R. F. R., B. I. C., E. P. F., A. N. S.], and Department of Lipid Research, Public Health Research Institute of The City of New York, Inc. [B. I. C., M. T.], New York, New York 10016

Diets rich in vegetables are associated with a low incidence of colon cancer. Since plant sterols are plentiful in vegetarian diets, we studied the effect of ß-sitosterol on colon tumor formation in rats treated with the carcinogen N-methyl-N-nitrosourea. We demonstrated that ß-sitosterol nullified in part the effect of this direct-acting carcinogen on the colon. We suggest that plant sterols may have a protective dietary action to retard colon tumor formation. The beneficial effects of vegetarian diets may be enhanced because of the presence of these compounds.

¹ This work was supported by Grant CA-18651 from NIH as part of the National Large Bowel Cancer Project and Grant 7326-03 from the Veterans Administration.

² To whom requests for reprints should be addressed.

Received 4/23/79. Accepted 11/ 6/79.

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