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Regression of Induced Keratoacanthomas in Anagen (Hair Growth Phase) Skin Grafts in Mice

Clinic of Dermatology, Antonius Hospital, Jan van Scorelstraat 2, 3583 CP Utrecht [C. G. R.], and Laboratory for Pathology, National Institute of Public Health, P. O. Box 1, 3720 BA Bilthoven [E. J. R., W. K.], The Netherlands

Transplants of experimental keratoacanthomas induced in skin grafts which were in the growth phase of the hair follicle cycle (anagen phase) were carried out in immunocompetent and immunoincompetent recipients ("nude" mouse, nu/nu). No differences in gross graft observations were noticed. More than 80% of all keratoacanthomas disappeared postgrafting. This percentage was the same for both groups of recipients. These data are in keeping with a nonimmunological regression of experimental keratoacanthomas. A possible correlation with the hair follicle cycle is suggested.

¹ To whom requests for reprints should be addressed.

Received 4/16/79. Accepted 1/24/80.