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Effect of Subcutaneously Administered 2,6,10,14-Tetramethylpentadecane on Plasmacytoma Growth¹

Research Institute of Joint Diseases Hospital North General, Mount Sinai School of Medicine, New York, New York 10035

2,6,10,14-Tetramethylpentadecane (pristane), s.c. injected simultaneously with plasmacytoma inocula, enhances the transplantability of tumor cells. The effect is dose and time dependent. The enhancement is shown only by plasmacytoma (MOPC-315 and MPC-11) and not by the murine lymphosarcoma and chondrosarcoma tested. Various mechanisms, such as stress and depression of humoral and cellular immunity, have been considered.

¹ This investigation was supported by Grant P 30 CA 14194, awarded by the National Cancer Institute, and Grant RR5589, awarded by the Biomedical Research Support Program, Division of Research Resources, Department of Health, Education, and Welfare.

² To whom requests reprints should be addressed.

Received 8/20/79. Accepted 3/19/80.