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Radioimmunodetection of Gastrointestinal Neoplasms with Antibodies to Carcinoembryonic Antigen¹

Department of Immunology, University of Birmingham [K. R. H., A. R. B., P. W. D.], and Department of Nuclear Medicine, Queen Elizabeth Hospital [T. A. R., Z. D.], Edgbaston, Birmingham 15, England

Primary and secondary gastrointestinal tumors have been identified using sheep immunoglobulin G antibody to carcinoembryonic antigen radiolabeled with ¹³¹I. ^99mTc-pertechnetate and ^99mTc-human serum albumin were used to identify tissue spaces and blood pool and to facilitate external subtraction imaging.

In 13 patients with tumors, 4 of 5 primary sites and 8 of 11 secondary sites were successfully demonstrated. Two patients with benign disease had negative scans. Comparison with conventional methods of scanning showed good correlation.

¹ Presented at the UICC Workshop on Radioimmunodetection of Cancer, July 19 to 21, 1979, Lexington, Ky. The work was supported by a grant from the Medical Research Council.