This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by DeLand, F. H. Articles by Goldenberg, D. M. Search for Related Content PubMed PubMed Citation Articles by DeLand, F. H. Articles by Goldenberg, D. M.

Lymphoscintigraphy with Radionuclide-labeled Antibodies to Carcinoembryonic Antigen¹

Department of Radiation Medicine [F. H. D.] and Division of Experimental Pathology, Department of Pathology [D. M. G.], University of Kentucky, College of Medicine, Nuclear Medicine Service of Veterans Administration Medical Center [E. E. K.], and the Ephraim McDowell Community Cancer Network, Inc., Lexington, Kentucky 40536

Upper- and lower-extremity lymphoscintigraphy was performed on 50 patients with proven carcinoma of the breast, gastrointestinal system, genitourinary tract, lung, and vulva; 42 patients had ¹³¹I-antibodies to carcinoembryonic antigen (CEA) and 8 patients had ¹³¹I-normal goat immunoglobulin G. All metastases in the axillary or inguinal lymph nodes were detected with the CEA antibodies. In nine patients without metastases, radioactivity was observed in inguinal or axillary nodes. It is postulated that the nodal sequestration of antibody in the absence of metastatic carcinoma is due to captured CEA in lymph nodes draining the tumor site. This study has demonstrated the high sensitivity for detecting nodal metastases by labeled antibodies to CEA draining from primary or recurrent tumors.

¹ Presented at the UICC Workshop on Radioimmunodetection of Cancer, July 19 to 21, 1979, Lexington, Ky. Supported by National Cancer Institute Grant CA-25584 and by the Veterans Administration Central Office, Washington, D. C.

² To whom requests for reprints should be addressed, at the University of Kentucky Medical Center, Room N-7, Lexington, Ky. 40536.