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Radiolabeling of Antibodies¹

Section of Radiopharmaceutical Chemistry, George Washington University Medical Center, Washington, D. C. 20037

The radiolabeling of antibodies is considered in terms of the choice of radionuclide, the method of conjugation, and the effect of conjugation on plasma clearance. Iodination techniques are reviewed, but the major emphasis is placed on the methods of conjugating metallic radionuclides using bifunctional chelating agents. The technique of producing clinically useful radiolabeled antibodies by balancing altered substrate specificity caused by radiolabeling against accelerated plasma clearance is discussed.

¹ Presented at the UICC Workshop on Radioimmunodetection of Cancer, July 19 to 21, 1979, Lexington, Ky. Supported in part by Grant CA 18675 awarded by the National Cancer Institute and Grant HL 19127 awarded by the Heart, Lung and Blood Institute.