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Imaging Approach in Radioimmunodetection¹

Departments of Radiation Medicine [F. H. D.] and Pathology [D. M. G.], University of Kentucky College of Medicine; Nuclear Medicine Service of Veterans Administration Medical Center [E. E. K., G. S.]; and The Ephraim McDowell Community Cancer Network, Inc., Lexington, Kentucky 40536

External in vivo imaging of tumors with radioactively labeled antibodies to tumor-associated antigens requires processing to remove interfering nontarget radioactivity. Processing entails the use of simulated nontarget compounds labeled with a radionuclide physically different from that on the antibody and subtraction of the simulated nontarget activity from the nontargeted antibody. A 2-fold increase of the target to nontarget radioactivity is achieved that has made possible a greater than 70% tumor detection rate.

¹ Presented at the UICC Workshop on Radioimmunodetection of Cancer, July 19 to 21, 1979, Lexington, Ky. Supported by National Cancer Institute Grant CA-25584 and by the Veterans Administration Central Office, Washington, D. C.

² To whom requests for reprints should be addressed, at the University of Kentucky Medical Center, Room N-7, Lexington, Ky. 40536