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Increase in Cellular RNA in Cells Infected with DNA Oncogenic Viruses¹

Fels Research Institute and Department of Pathology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140 [S. P., K. J. S., S. P., R. B.], and Memorial Sloan Kettering Cancer Center, New York, New York 10021 [Z. D., F. T.]

The amount of RNA per cell has been measured by flow microfluorometry in cultured cells stimulated by serum or infected with DNA oncogenic viruses (SV40, polyoma virus, and adenovirus). While all four agents stimulate, although to a different extent, cellular DNA synthesis in quiescent cells, the accumulation of cellular RNA varies. Serum, SV40, and polyoma virus cause a marked increase in total cellular RNA that is already apparent in G₁ cells before entry into S. On the other hand, adenovirus 2, while capable of stimulating cellular DNA synthesis, fails to detectably increase the amount of RNA per cell. These results suggest that adenovirus 2 may act on quiescent cells through mechanisms different from those of serum, SV40, or polyoma virus.

¹ This work was supported by USPHS Research Grants CA 25898, CA 12923, and 1-26-CA-14134 from the National Cancer Institute.

² Recipient of National Cancer Institute Training Grant CA 09214.

³ Recipient of a fellowship from the National Institute on Aging (AG 05103).

Received 11/29/79. Accepted 6/ 6/80.

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