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Immunotherapy of the Guinea Pig Line 10 Hepatocarcinoma with a Variety of Nonviable Bacteria¹

National Jewish Hospital and Research Center, Denver, Colorado 80206

A variety of heat-killed bacteria were tested for their capacity to induce regressions of established line 10 hepatocarcinomas in syngeneic guinea pigs. Multiple intralesional injections of heat-killed Escherichia coli, Streptococcus mutans, Listeria monocytogenes, and Propionibacterium acnes resulted in complete regression of the tumor in a majority of guinea pigs. Repeated injections of heat-killed Mycobacterium bovis strain Bacillus Calmette-Guérin caused no regressions. Surviving animals were immune to subsequent challenge with line 10 cells but not L₂C cells, another syngeneic tumor.

¹ Supported by Grant CA-15446 awarded by the National Cancer Institute, Department of Health, Education and Welfare.

² Recipient of Fellowship CA-05533 awarded by the National Cancer Institute, Department of Health, Education and Welfare. Present address: Laboratory of Immunodiagnosis, National Cancer Institute, Bethesda, Md. 20205.

³ Recipient of Fellowship CA-06362 awarded by the National Cancer Institute, Department of Health, Education and Welfare.

⁴ Recipient of Fellowship CA-05214 awarded by the National Cancer Institute, Department of Health, Education and Welfare. Present address: Department of Surgery, Kansas State University, Manhattan, Kans. 66502.

⁵ To whom requests for reprints should be addressed, at Department of Medicine, National Jewish Hospital and Research Center, 3800 East Colfax Avenue, Denver, Colo., 80206.

Received 2/ 7/80. Accepted 6/ 9/80.