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Relationship of Presence of Progesterone Receptors to Prognosis in Early Breast Cancer¹

Groupe de Recherches sur la Biochimie Endocrinienne et la Reproduction (INSERM U. 135), Faculté de Médecine Paris-Sud, 94270 Bicétre [M-F. P., E. M.], and Centre René Huguenin de Lutte contre le Cancer 92211 Saint-Cloud [C. P., M. B.] France

The presence of progesterone receptors was found to be associated with a favorable prognosis in 98 patients with primary breast cancer. The occurrence of metastases was 3.6 times less probable in patients with progesterone receptor-positive tumors than in patients with progesterone receptor-negative tumors. There was also an inverse relationship between the concentration of progesterone receptor and the frequency of metastases. However, there was no statistical correlation between frequency of local recurrences and progesterone receptor content of the tumor.

In patients displaying clinical or histological criteria of gravity, the presence of progesterone receptors allowed us to define subgroups with good prognosis. Thus, in women with progesterone receptor-positive cancers, metastases had occurred at 18 months, in only 5% of the 39 Grade III cancers and in none of the 25 cases with invaded axillary nodes.

Measurement of estradiol receptor (105 patients including the previous 98 patients) was found to be less effective for guiding the prognosis of early breast cancer. Combined evaluation of estradiol and progesterone receptors did not provide any more information than did the determination of progesterone receptor alone.

¹ This work was supported by the Institut National de la Santé et de la Recherche Médicale (CRAT 76.4.490, ATP 24.75.47), the Fondation pour la Recherche Médicale Française, the Ligue Nationale contre le Cancer, and the UER Kremlin-Bicêtre.

² To whom requests for reprints should be addressed.

Received 9/13/79. Accepted 5/27/80.

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