| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
The Chemical Industry Institute of Toxicology [J. A. S., E. J. G.], Research Triangle Park, North Carolina 27709, and Battelle Columbus Laboratories, [W. D. K., R. I. M., K. L. P.], Columbus, Ohio 43201
Groups of 120 male and 120 female rats were exposed by inhalation to 0, 2, 6, or 15 ppm formaldehyde vapor 6 hr/day, 5 days/week, for 18 months of a 24-month study. The present communication describes interim findings based on data available after 18 months of exposure. Squamous cell carcinomas occurred in the nasal cavities of 36 rats exposed to 15 ppm formaldehyde. The tumors ranged from small early carcinomas of the nasal turbinate to large invasive osteolytic neoplasms which extended into the subcutis of the premaxilla. Similar tumors were not detected in rats exposed for 18 months to 2 or 6 ppm or in mice exposed to 2, 6, or 15 ppm formaldehyde. Rhinitis, epithelial dysplasia, and squamous metaplasia occurred in rats from all exposure levels of formaldehyde; however, the severity and extent of the lesions were dose related. In contrast, papillary hyperplasia and squamous atypia occurred only in animals exposed to 15 ppm formaldehyde.
1 To whom requests for reprints should be addressed.
Received 4/ 8/80. Accepted 6/16/80.
This article has been cited by other articles:
|
|
 |
|
  C. Kum, S. Sekkin, F. Kiral, and F. Akar Effects of xylene and formaldehyde inhalations on renal oxidative stress and some serum biochemical parameters in rats Toxicology and Industrial Health, March 1, 2007; 23(2): 115 - 120. [Abstract] [PDF]
|
|
|
|
 |
|
 R. A. Renne, K. M. Gideon, S. J. Harbo, L. M. Staska, and S. L. Grumbein Upper Respiratory Tract Lesions in Inhalation Toxicology Toxicol Pathol, January 1, 2007; 35(1): 163 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. T. Chang and H.-O. Adami The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol. Biomarkers Prev., October 1, 2006; 15(10): 1765 - 1777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gulec, A. Songur, S. Sahin, O. A Ozen, M. Sarsilmaz, and O. Akyol Antioxidant enzyme activities and lipid peroxidation products in heart tissue of subacute and subchronic formaldehyde-exposed rats: a preliminary study Toxicology and Industrial Health, April 1, 2006; 22(3): 117 - 124. [Abstract] [PDF]
|
|
|
|
|
|
J. R. Harkema, S. A. Carey, and J. G. Wagner The Nose Revisited: A Brief Review of the Comparative Structure, Function, and Toxicologic Pathology of the Nasal Epithelium Toxicol Pathol, April 1, 2006; 34(3): 252 - 269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Conolly, J. S. Kimbell, D. Janszen, P. M. Schlosser, D. Kalisak, J. Preston, and F. J. Miller Human Respiratory Tract Cancer Risks of Inhaled Formaldehyde: Dose-Response Predictions Derived From Biologically-Motivated Computational Modeling of a Combined Rodent and Human Dataset Toxicol. Sci., November 1, 2004; 82(1): 279 - 296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L E Pinkerton, M J Hein, and L T Stayner Mortality among a cohort of garment workers exposed to formaldehyde: an update Occup. Environ. Med., March 1, 2004; 61(3): 193 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M Marsh, A. O Youk, J. M Buchanich, L. D Cassidy, L. J Lucas, N. A Esmen, and I. M Gathuru Pharyngeal cancer mortality among chemical plant workers exposed to formaldehyde Toxicology and Industrial Health, July 1, 2002; 18(6): 257 - 268. [Abstract] [PDF]
|
|
|
|
|
|
J. H. Overton, J. S. Kimbell, and F. J. Miller Dosimetry Modeling of Inhaled Formaldehyde: The Human Respiratory Tract Toxicol. Sci., November 1, 2001; 64(1): 122 - 134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. J. M. van Birgelen, B. J. Chou, R. A. Renne, S. L. Grumbein, J. H. Roycroft, J. R. Hailey, and J. R. Bucher Effects of Glutaraldehyde in a 2-Year Inhalation Study in Rats and Mice Toxicol. Sci., May 1, 2000; 55(1): 195 - 205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. C. Roe Priorities for Research in the Field of Indoor Air Pollution Indoor and Built Environment, July 1, 1994; 3(4): 191 - 199. [Abstract] [PDF]
|
|
|
|
|
|
K. S. Sidhu, J. L. Hesse, and A. W. Bloomer Indoor Air: Potential Health Risks Related to Residential Wood Smoke, as Determined under the Assumptions of the US EPA Risk Assessment Model Indoor and Built Environment, March 1, 1993; 2(2): 92 - 97. [Abstract] [PDF]
|
|
|
|
|
|
F.J.C. Roe and D. Wood Review : Acetaldehyde and Formaldehyde: Is There a Cancer Risk for Man? Indoor and Built Environment, January 1, 1992; 1(1): 8 - 15. [Abstract] [PDF]
|
|
|
|
 |
|
 R. D. Smith Disaster Recovery: Problems and Procedures IFLA Journal, January 1, 1992; 18(1): 13 - 24. [PDF]
|
|
|
|
|
|
R. A. Renne, H. R. Brown, and M. P. Jokinen Morphology of Nasal Lesions Induced in Osborne-Mendel Rats and B6C3F1 Mice by Chronic Inhalation of Allyl Glycidyl Ether Toxicol Pathol, January 1, 1992; 20(3-1): 416 - 425. [Abstract] [PDF]
|
|
|
|
|
|
M. B. G. St. Clair, E. A. Gross, and K. T. Morgan Pathology and Cell Proliferation Induced by Intra-nasal Instillation of Aldehydes in the Rat: Comparison of Glutaraldehyde and Formaldehyde Toxicol Pathol, April 1, 1990; 18(3): 353 - 361. [Abstract] [PDF]
|
|
|
|
 |
|
 Council on Scientific Affairs Formaldehyde JAMA, February 24, 1989; 261(8): 1183 - 1187. [Abstract] [PDF]
|
|
|
|
|
|
M. Soffritti, C. Maltoni, F. Maffei, and R. Biagi Formaldehyde: An Experimental Multipotential Carcinogen Toxicology and Industrial Health, January 1, 1989; 5(5): 699 - 730. [Abstract] [PDF]
|
|
|
|
|
|
Universities Associated for Research and Education Epidemiology of Chronic Occupational Exposure To Formaldehyde: Report of the Ad Hoc Panel On Health Aspects of Formaldehyde Toxicology and Industrial Health, January 1, 1988; 4(1): 77 - 90. [Abstract] [PDF]
|
|
|
|
|
|
M. Shiba, A. C. Marchok, A. J. P. Klein-Szanto, and Y. Yamaguchi Pathological Changes Induced by Formaldehyde in Open-Ended Rat Tracheal Implants Preexposed to Benzo(a)pyrene Toxicol Pathol, June 1, 1987; 15(4): 401 - 408. [Abstract] [PDF]
|
|
|
|
|
|
W. K. Lutz Endogenous Formaldehyde Does Not Produce Detectable DNA-Protein Crosslinks in Rat Liver Toxicol Pathol, April 1, 1986; 14(4): 462 - 465. [Abstract] [PDF]
|
|
|
|
 |
|
 D.M. Ranly, D. Horn, and T. Zislis The Effect of Alternatives to Formocresol on Antigenicity of Proteins Journal of Dental Research, October 1, 1985; 64(10): 1225 - 1228. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Grafstrom, R. Curren, L. Yang, and C. Harris Genotoxicity of formaldehyde in cultured human bronchial fibroblasts Science, April 5, 1985; 228(4695): 89 - 91. [Abstract] [PDF]
|
|
|
|
 |
|
 6 Final Report on the Safety Assessment of Formaldehyde International Journal of Toxicology, May 1, 1984; 3(3): 157 - 184. [Abstract] [PDF]
|
|
|
|
|
|
1 Final Report on the Safety Assessment of Sodium Laureth Sulfate and Ammonium Laureth Sulfate International Journal of Toxicology, September 1, 1983; 2(5): 1 - 34. [Abstract] [PDF]
|
|
|
|
|
|
R. Grafstrom, A. Fornace Jr, H Autrup, J. Lechner, and C. Harris Formaldehyde damage to DNA and inhibition of DNA repair in human bronchial cells Science, April 8, 1983; 220(4593): 216 - 218. [Abstract] [PDF]
|
|
|
|
|
|
W. E. Halperin, M. Goodman, L. Stayner, L. J. Elliott, R. A. Keenlyside, and P. J. andrigan Nasal Cancer in a Worker Exposed to Formaldehyde JAMA, January 28, 1983; 249(4): 510 - 512. [Abstract] [PDF]
|
|
|
|
|
|
F Perera and C Petito Formaldehyde: a question of cancer policy? Science, June 18, 1982; 216(4552): 1285 - 1291. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
