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Steroid Hormone Accumulation in Human Breast Cyst Fluid¹

The Rockefeller University and Memorial Sloan Kettering Cancer Center, New York, New York 10021, and Institute for Steroid Research, Montefiore Hospital and Medical Center, Bronx, New York 10467

Elevated concentrations of peptide hormones have been described previously in human breast fluid. In the current study, the levels of cortisol, progesterone, testosterone, dihydrotestosterone, androsterone, androsterone sulfate, dehydroisoandrosterone, dehydroisoandrosterone sulfate, estradiol, estrone, estradiol sulfate, and estrone sulfate were measured. The levels of the four 17-ketosteroids and the two estrogen sulfates were markedly elevated over the plasma level, while that of the other compounds was the same or only slightly higher than the plasma levels of the same compounds.

¹ This work was supported by Contract NCI-CB 53853-37, "Biochemical Analysis of Human Breast Cyst Fluid and its Correlation with Development of Breast Cancer," awarded by the National Cancer Institute, Department of Health, Education, and Welfare, and Grant CA 22795 from the National Cancer Institute.

² To whom requests for reprints should be addressed, at: The Rockefeller University, 1230 York Avenue, New York, N. Y. 10021.

Received 6/13/80. Accepted 9/26/80.

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