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Screening Trial with the Coordinated Gold Compound Auranofin Using Mouse Lymphocytic Leukemia P388¹

Arthritis Center, Memorial Hospital Medical Center of Long Beach, Long Beach, California 90801

The coordinated gold compound, 2,3,4,6-tetra-O-acetyl-1-thio-ß-D-glucopyranosato-S-triethylphosphine-gold (Auranofin) was found to be effective in increasing the life span of C57BL x DBA/2 F₁ mice inoculated with the lymphocytic leukemia P388. A number of dose schedules were used, the lowest dose being 6 mg/kg every fourth day and the highest dose being 6.0 mg/kg twice daily for 9 days; the lowest and highest doses produced treated versus control ratios of 140 and 220%, respectively. All treatment groups achieved the minimum treated versus control ratio of 125%. Animal weights remained stable at twice-daily and high-dose-daily regimens. Increased life span and weight changes were both found to correlate with drug concentration and/or dose frequency.

¹ Supported in part by a grant from Smith, Kline & French Laboratories, Philadelphia, Pa.; The Rheumatic Diseases Research Foundation; and an institutional grant from Memorial and Children's Medical Center Foundation.

² To whom requests for reprints should be addressed, at Department of Rheumatology, Memorial Hospital Medical Center of Long Beach, 2801 Atlantic Avenue, Long Beach, Calif. 90801.

Received 5/ 8/80. Accepted 9/26/80.

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