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Cell-specific Cytotoxicity Expressed by a Conjugate of Ricin and Murine Monoclonal Antibody Directed against Thy 1.1 Antigen

Department of Biochemistry, University of Kansas, Lawrence, Kansas 66045 [L. L. H.], and Fred Hutchinson Cancer Research Center, Seattle, Washington 98104 [R. C. N.]

The isolation and characterization are described of a conjugate between ricin₁ and a Thy 1.1-specific monoclonal IgG_2a murine antibody synthesized using N-succinimidyl-3-(2-pyridyldithio)propionate. The conjugate selectively inhibited protein synthesis in Thy 1.1-positive (AKR SL3) mouse leukemia cells compared to Thy 1.2-positive (AKR/Cu SL1) cells.

¹ Recipient of a Research Career Development Award (CA 00114) from the National Cancer Institute. To whom requests for reprints should be addressed.

Received 1/ 5/81. Accepted 7/10/81.

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