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Self-Renewal Capacity of Leukemic Blast Progenitor Cells¹

Ontario Cancer Institute [R. N. B., J-A. C., H. A. M., J. E. C., E. A. M.], Department of Medical Biophysics [R. N. B.], Department of Medicine [H. A. M., J. E. C., E. A. M.], and Institute of Medical Sciences [J-A. C., E. A. M.], University of Toronto, Toronto, Ontario, Canada M58 IAI

A review is presented of experimental information pertaining to the characteristics of a procedure designed to quantitate the capacity for self-renewal in clonogenic cells of human acute myeloblastic leukemia. In a series of 44 previously untreated patients, a significant correlation (p < 0.01) was seen between low capacity for self-renewal and successful remission induction. Three cytotoxic drugs (Adriamycin, 1-ß-D-arabinofurano-sylcytosine, and N-[4-(19-acridinylamino)-3-methoxyphenyl]-methanesulfonamide) were tested for preferential effect against self-renewal events. Surviving clonogenic cells to these agents had, respectively, unchanged, lower, and higher capacity for self-renewal. The implications of such drug properties are discussed.

¹ Presented at the Conference on Cell Markers in Acute Leukemia, March 4 and 5, 1980, Bethesda, Md. Supported in parts by grants from the Ontario Cancer Treatment and Research Foundation, Medical Research Council of Canada.

² Recipient of a grant from the National Leukemia Association.

³ Recipient of a grant from the National Cancer Institute of Canada.