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A Mitogenic Factor for Transformed Fibroblasts from Human Platelets¹

Departments of Medicine [N. K., A. L.] and Microbiology [A. L.] and The Specialized Cancer Research Center [A. L.], The Milton S. Hershey Medical Center of The Pennsylvania State University, Hershey, Pennsylvania 17033

Human platelets contain discrete glycoproteins that promote the growth of 3T3 (platelet-derived growth factor 1) and SV3T3 (platelet-derived growth factor 2) cells. The factor that promotes the growth of SV3T3 cells is a heat-labile nondialyzable glycoprotein with an isoelectric point of 7.8 to 8.3.

¹ This work was supported by Grant PCM 7922936 from the National Science Foundation.

² To whom requests for reprints should be addressed.

Received 7/16/79. Accepted 10/16/80.

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