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Enhancement by Urine of Urinary Bladder Carcinogenesis¹

Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611

The role of urine as a tumor-enhancing agent in urinary bladder carcinogenesis was investigated by using the heterotopically transplanted rat urinary bladder. Bladders removed from rats initiated with the carcinogen N-butyl-N-(4-hydroxy-butyl)nitrosamine in drinking water for 4 or 10 weeks were heterotransplanted to syngeneic rats. Those heterotopically transplanted bladders receiving repeated instillations of normal rat urine subsequent to transplantation had a higher incidence of carcinoma than did those receiving 0.9% NaCl solution. These results suggest that normal urine may contain tumor promoter(s).

¹ Supported by USPHS Grant CA 14649 through the National Bladder Cancer Project and Northwestern University Medical School, Department of Pathology Funds.

² To whom requests for reprints should be addressed.

³ Present address: Department of Urology, Nara Medical University, Kashihara, Nara, Japan.

⁴ Present address: Department of Pathology, Tokushima University School of Medicine, Tokushima, Japan.

Received 7/30/80. Accepted 11/ 4/80.

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