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Excretion of Carcinoma Products in Irradiated C3H/He Mice¹

Department of Experimental Pathology, Roswell Park Memorial Institute, Buffalo, New York 14263 [J. V.], and Departments of Obstetrics and Gynecology [B. A.] and Therapeutic Radiology [A. C.], Tufts New England Medical Center, Boston, Massachusetts 02111

Local low-dose (200 rads) -irradiation to both kidneys impaired the excretion of ³H-labeled tumor products and reduced the survival time of mice carrying carcinomas in the ascites form. Daily i.p. injections of cell-free ascites fluid into tumor-free mice for 3 weeks resulted in the death of 25 of 180 irradiated animals, with no deaths among 180 injected unirradiated controls. The only histologically visible effects of irradiation of the kidneys during ascites tumor growth or during i.p. injections of cell-free ascites fluid was a cloudy swelling of the tubular epithelium in the renal cortex together with excessive protein in the tubular lumens.

¹ Supported by Grants CA-15960 and CA-16683 awarded by the National Cancer Institute, Department of Health, Education, and Welfare. The work was started at Pondville Hospital, Walpole, Mass., and was completed at the Roswell Park Memorial Institute.

Received 1/14/80. Accepted 10/31/80.