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Effect of Dose of Sodium Saccharin on the Induction of Rat Urinary Bladder Proliferation¹

Department of Pathology. St. Vincent Hospital, Worcester, Massachusetts 01604

The effect of sodium saccharin fed to male F344 rats at levels of 5.0, 2.5, 1.0, 0.5, and 0.1% of the diet for 10 weeks was evaluated by autoradiography and scanning electron microscopy. A dose response was evident with both techniques. The labeling index was statistically significantly elevated at all doses above 0.1%. As observed by scanning electron microscopy, the number of foci containing ropy microridges or uniform microvilli was elevated at doses of 1.0, 2.5, and 5.0% of the diet, and pleomorphic microvilli were observed at the two highest doses.

¹ Supported in part by USPHS Grant CA15945 from the National Cancer Institute through the National Bladder Cancer Project.

² To whom requests for reprints should be addressed.

Received 9/11/80. Accepted 12/ 5/80.