| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Life Sciences Division, IIT Research Institute, Chicago, Illinois 60616
Dose-response relationships for the induction of mammary tumors by a single i.v. injection of N-methyl-N-nitrosourea (MNU) were studied. At 50 days of age, groups of 20 virgin female Sprague-Dawley rats received single doses of 50, 45, 40, 35, 30, 25, 20, 15, or 10 mg MNU per kg body weight; a group of 10 control rats received 0.85% NaCl solution only. Animals were observed for the appearance of mammary tumors over their life span or until 600 days after carcinogen administration. Both malignant and benign mammary tumors appeared in all groups; however, malignant tumors appeared earlier and at a faster rate than did benign tumors. Incidence of cancer and number of cancers per animal increased with increasing MNU dose; the latent period for cancer increased with decreasing dose. The number of benign tumors induced as a percentage of total tumors increased with decreasing dose, ranging from approximately 10% in groups receiving more than 30 mg MNU per kg to 58% in the group receiving 10 mg/kg. Foci of metastatic mammary carcinoma were found in lungs of animals in several MNU dose groups. Data from the present study indicate that a single i.v. administration of MNU induces mammary cancer in a dose-related fashion, with little toxicity and a short latent period; induced cancers metastasize to distant sites. The single-dose MNU model thus appears to be superior to both the 7,12-dimethylbenz(a)anthracene and multiple-dose MNU models, particularly for use in studies of modification of mammary carcinogenesis.
1 Supported in part by Contracts N01-CP-23292 and N01-CP-75939 from the National Cancer Institute.
2 To whom requests for reprints should be addressed, at Life Sciences Division, IIT Research Institute, 10 West 35th Street, Chicago, Ill. 60616.
Received 11/ 7/80. Accepted 1/29/81.
This article has been cited by other articles:
|
|
 |
|
  J. Kotsopoulos, K.-J. Sohn, R. Martin, M. Choi, R. Renlund, C. Mckerlie, S. W. Hwang, A. Medline, and Y.-I. J. Kim Dietary folate deficiency suppresses N-methyl-N-nitrosourea-induced mammary tumorigenesis in rats Carcinogenesis, May 1, 2003; 24(5): 937 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. P. L. Bhat, D. Lantvit, K. Christov, R. G. Mehta, R. C. Moon, and J. M. Pezzuto Estrogenic and Antiestrogenic Properties of Resveratrol in Mammary Tumor Models Cancer Res., October 1, 2001; 61(20): 7456 - 7463. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Rajkumar, R. C. Guzman, J. Yang, G. Thordarson, F. Talamantes, and S. Nandi Short-term exposure to pregnancy levels of estrogen prevents mammary carcinogenesis PNAS, September 25, 2001; 98(20): 11755 - 11759. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. E. Steele, C. A. Holmes, E. T. Hawk, L. Kopelovich, R. A. Lubet, J. A. Crowell, C. C. Sigman, and G. J. Kelloff Lipoxygenase Inhibitors as Potential Cancer Chemopreventives Cancer Epidemiol. Biomarkers Prev., May 1, 1999; 8(5): 467 - 483. [Abstract] [Full Text]
|
|
|
|
|
|
Y.-C. Chou, R. C. Guzman, S. M. Swanson, J. Yang, H. M. Lui, V. Wu, and S. Nandi Induction of mammary carcinomas by N-methyl-N-nitrosourea in ovariectomized rats treated with epidermal growth factor Carcinogenesis, April 1, 1999; 20(4): 677 - 684. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. D. Staren, M. S. Sabel, L. M. Gianakakis, G. A. Wiener, V. M. Hart, M. Gorski, K. Dowlatshahi, B. F. Corning, M. F. Haklin, and G. Koukoulis Cryosurgery of Breast Cancer Arch Surg, January 1, 1997; 132(1): 28 - 33. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
