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Specificity of Bleomycin-induced Cytotoxic Effects on Ataxia Telangiectasia Lymphoid Cell Lines¹

Division of Genetics, Department of Pediatrics, Northwestern University Medical School, Children's Memorial Hospital, Chicago, Illinois 60614

Bleomycin exposure evoked a specific sensitivity in five ataxia telangiectasia (AT) long-term lymphoblastoid cell lines when compared to lines derived from four normal individuals or three patients with xeroderma pigmentosum. At all concentrations tested or after each treatment regimen, statistically significant differences in viability and cytogenetic damage were obvious, with the AT cell lines demonstrating reduced survival and increased chromosomal breakage. However, similar differences were not observed following treatment of all cell lines with mitomycin C. The normal and xeroderma pigmentosum cells appear capable of overcoming the effects of bleomycin during a 48- or 72-hr recovery period while the AT cell lines could not. This specific response to bleomycin constitutes the first demonstration of increased chromosome breakage in vitro in long-term AT lymphoblastoid cell lines.

¹ This study was supported in part by a grant from The March of Dimes Birth Defects Foundation.

² To whom requests for reprints should be addressed, at The Children's Memorial Hospital, 2300 Children's Plaza, Chicago, Ill. 60614.

Received 9/18/80. Accepted 2/ 4/81.

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