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Occurrence of the Low-Mobility H1 Histone Subfraction in Embryonic, Differentiated, and Neoplastic Tissues of the Syrian Hamster¹

Jacek K. Bartkowiak, Gabriela M. Graczyk, Anna Pucienniczak, Anna Jasiska and Henryk T. Panusz

Department of Biochemistry, Institute of Physiology and Biochemistry [H. T. P.], and Department of Oncology [J. K. B., G. M. G., A. P., A. J.], The School of Medicine in odz, 90-131 odz, Poland

Electrophoretically slow H1 histone subfractions with mobilities identical to that of the subfraction found in the Kirkman-Robbins hamster hepatoma chromatin have been shown to be present in 12-day hamster embryos and in a sarcoma-type hamster tumor induced by SV40. No subfractions of such mobility were found in hamster liver, regenerating liver, thymus, spleen, and a fast-growing transplantable amelanotic hamster melanoma. A suggestion is made that some defective mechanisms of differentiation may affect the regulation of expression of the genes coding for the H1 histone subfractions. The same mechanisms may possibly but not necessarily be connected with the molecular events leading to neoplastic growth.

¹ This work was supported by the Polish National Cancer Programme Grant PR-6, 1311.

Received 7/21/80. Accepted 2/ 4/81.