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Effect of Two Kinds of Pectin and Guar Gum on 1,2-Dimethylhydrazine Initiation of Colon Tumors and on Fecal ß-Glucuronidase Activity in the Rat¹

Department of Surgery, University Hospital of Lund [H. G. B., P. E. F.], and Department of Nutrition, Chemical Center [N. G. A., A. D., M. N., R. Ö.], S-221 85 Lund 7 Sweden

The effect of 5% low-methoxylated pectin, high-methoxylated pectin, and guar gum on 1,2-dimethylhydrazine initiation of colon cancer was investigated using groups of 30 rats. The growth of the rats in the different groups was very similar to that of a control group fed a fiber-free diet.

Both kinds of pectin increased the multiplicity of colon tumors, whereas guar gum did not significantly influence carcinogenesis.

Bacterial ß-glucuronidase activity in feces and colonic content was the same in pectin-fed rats and controls but significantly lower in the guar gum group. Thus, it was not related to the number of tumors in each group.

¹ Supported by the John and Augusta Persson Foundation for Scientific and Medical Research; the Medical Faculty of the University of Lund, Sweden; The Swedish Medical Research Council, Project 03X-4745; and the Swedish Nutrition Foundation.

² To whom requests for reprints should be addressed.

Received 9/17/80. Accepted 2/25/81.

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