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Release of Monoclonal Antibody-defined Antigens by Human Colorectal Carcinoma and Melanoma Cells¹

Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104

Many but not all of the cell surface antigens studied were released into tissue culture medium of human colorectal carcinoma and melanoma cells maintained in vitro. Two groups of monoclonal antibody-defined antigens are described. One group is composed of molecules that are released easily and in large quantities into the tissue culture milieu. In this group, four glycolipid antigens of colon carcinoma, including a monosialoganglioside, and five glycoproteins of melanoma were detected in tissue culture supernatants. Antigens of the second group could not be detected in tissue culture supernatants. This group included one colorectal carcinoma antigen, the nature of which is unknown, and a glycoprotein of melanoma cells.

¹ Supported in part by Grants CA-10815, CA-21124, CA-25298, and CA-25874 from the National Cancer Institute; Grant RR-05540 from the Division of Research Resources; and funds from W. W. Smith Foundation.

² To whom requests for reprints should be addressed.

Received 1/16/81. Accepted 4/13/81.

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