| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455
The effects of sodium cyanate, tert-butyl isocyanate, and benzyl isothiocyanate on carcinogen-induced neoplasia were studied in experiments in which the test compound was fed starting 1 week following completion of carcinogen administrations. Under these conditions, all three test compounds exerted an inhibitory effect on the occurrence of 7,12-dimethylbenz(a)anthracene-induced neoplasia of the breast of Sprague-Dawley rats. In a second experiment model, sodium cyanate inhibited the occurrence of 1,2-dimethylhydrazine-induced neoplasia of the large bowel of female CF-1 mice. Thus, a new group of compounds has been identified which has inhibitory capacities against neoplasia when given subsequent to carcinogen exposure.
1 Supported by USPHS Research Grants CA-15638 through the National Large Bowel Cancer Project and CA-14146, both from the National Cancer Institute.
Received 2/13/81. Accepted 4/22/81.
This article has been cited by other articles:
|
|
 |
|
  D. Xiao, V. Vogel, and S. V. Singh Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak. Mol. Cancer Ther., November 1, 2006; 5(11): 2931 - 2945. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Y.A. Plate and D. D. Gallaher Effects of Indole-3-Carbinol and phenethyl isothiocyanate on colon carcinogenesis induced by azoxymethane in rats Carcinogenesis, February 1, 2006; 27(2): 287 - 292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Miyoshi, S. Takabayashi, T. Osawa, and Y. Nakamura Benzyl isothiocyanate inhibits excessive superoxide generation in inflammatory leukocytes: implication for prevention against inflammation-related carcinogenesis Carcinogenesis, April 1, 2004; 25(4): 567 - 575. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Miyoshi, K. Uchida, T. Osawa, and Y. Nakamura A Link between Benzyl Isothiocyanate-Induced Cell Cycle Arrest and Apoptosis: Involvement of Mitogen-Activated Protein Kinases in the Bcl-2 Phosphorylation Cancer Res., March 15, 2004; 64(6): 2134 - 2142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. W.Y. Lui, A. L. Wentzel, D. Xiao, K. L. Lew, S. V. Singh, and J. R. Grandis Requirement of a carbon spacer in benzyl isothiocyanate-mediated cytotoxicity and MAPK activation in head and neck squamous cell carcinoma Carcinogenesis, October 1, 2003; 24(10): 1705 - 1712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Hu, B. R. Kim, C. Chen, V. Hebbar, and A.-N.T. Kong The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells Carcinogenesis, August 1, 2003; 24(8): 1361 - 1367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Fowke, F.-L. Chung, F. Jin, D. Qi, Q. Cai, C. Conaway, J.-R. Cheng, X.-O. Shu, Y.-T. Gao, and W. Zheng Urinary Isothiocyanate Levels, Brassica, and Human Breast Cancer Cancer Res., July 15, 2003; 63(14): 3980 - 3986. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-R. Chen, J. Han, R. Kori, A.-N. T. Kong, and T.-H. Tan Phenylethyl Isothiocyanate Induces Apoptotic Signaling via Suppressing Phosphatase Activity against c-Jun N-terminal Kinase J. Biol. Chem., October 11, 2002; 277(42): 39334 - 39342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Kassie, S. Rabot, M. Uhl, W. Huber, H. M. Qin, C. Helma, R. Schulte-Hermann, and S. Knasmuller Chemoprotective effects of garden cress (Lepidium sativum) and its constituents towards 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ)-induced genotoxic effects and colonic preneoplastic lesions Carcinogenesis, July 1, 2002; 23(7): 1155 - 1161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nakamura, M. Kawakami, A. Yoshihiro, N. Miyoshi, H. Ohigashi, K. Kawai, T. Osawa, and K. Uchida Involvement of the Mitochondrial Death Pathway in Chemopreventive Benzyl Isothiocyanate-induced Apoptosis J. Biol. Chem., March 1, 2002; 277(10): 8492 - 8499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Morimitsu, Y. Nakagawa, K. Hayashi, H. Fujii, T. Kumagai, Y. Nakamura, T. Osawa, F. Horio, K. Itoh, K. Iida, et al. A Sulforaphane Analogue That Potently Activates the Nrf2-dependent Detoxification Pathway J. Biol. Chem., January 25, 2002; 277(5): 3456 - 3463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang Molecular mechanism of rapid cellular accumulation of anticarcinogenic isothiocyanates Carcinogenesis, March 1, 2001; 22(3): 425 - 431. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. C. Goosen, D. E. Mills, and P. F. Hollenberg Effects of Benzyl Isothiocyanate on Rat and Human Cytochromes P450: Identification of Metabolites Formed by P450 2B1 J. Pharmacol. Exp. Ther., January 1, 2001; 296(1): 198 - 206. [Abstract] [Full Text]
|
|
|
|
|
|
K. R.K. Sticha, M. E. Staretz, M. Wang, H. Liang, P. M.J. Kenney, and S. S. Hecht Effects of benzyl isothiocyanate and phenethyl isothiocyanate on benzo[a]pyrene metabolism and DNA adduct formation in the A/J mouse Carcinogenesis, September 1, 2000; 21(9): 1711 - 1719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nakamura, H. Ohigashi, S. Masuda, A. Murakami, Y. Morimitsu, Y. Kawamoto, T. Osawa, M. Imagawa, and K. Uchida Redox Regulation of Glutathione S-Transferase Induction by Benzyl Isothiocyanate: Correlation of Enzyme Induction with the Formation of Reactive Oxygen Intermediates Cancer Res., January 1, 2000; 60(2): 219 - 225. [Abstract] [Full Text]
|
|
|
|
 |
|
 F. Kassie, B. Pool-Zobel, W. Parzefall, and S. Knasmuller Genotoxic effects of benzyl isothiocyanate, a natural chemopreventive agent Mutagenesis, November 1, 1999; 14(6): 595 - 604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Hecht Chemoprevention of Cancer by Isothiocyanates, Modifiers of Carcinogen Metabolism J. Nutr., March 1, 1999; 129(3): 768 - 768. [Abstract] [Full Text]
|
|
|
|
|
|
Y.-R. Chen, W. Wang, A.-N. T. Kong, and T.-H. Tan Molecular Mechanisms of c-Jun N-terminal Kinase-mediated Apoptosis Induced by Anticarcinogenic Isothiocyanates J. Biol. Chem., January 16, 1998; 273(3): 1769 - 1775. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
