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Chromosome Analysis of a Human Neuroblastoma¹

Divisions of Teratology and Genetics [M. M. H., S. W. S.] and Hematology and Oncology [J. E. N.], Children's Hospital Research Foundation, Cincinnati, Ohio 45229

Samplings of tumor cells from a patient with Stage IV neuroblastoma were analyzed for chromosome constitution. Chromosome preparations of the tumor cells from a bone marrow sample were compared to preparations of a solid metastatic tumor after growth in the nude mouse host or followed by culture. Six separate chromosome studies were done. The tumor karyotype demonstrated an overall stability, maintaining the consistent abnormalities of a 1p-, +17, and -22. Chromosomes 5 and 9 were also involved in structural abnormalities in sublines of the tumor cells. Double minutes were seen in all preparations.

¹ Supported by USPHS Grants R01-CA18588 from the National Cancer Institute, P30-HD05221 from the National Institute of Child Health and Human Development, and R23CA26956 from the NIH.

² To whom requests for reprints should be addressed.

Received 12/22/80. Accepted 4/22/81.

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