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Characterization of the Epstein-Barr Virus Isolated from a Cell Line Derived from a Patient with American Burkitt's Lymphoma

Infectious Disease Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20205

Epstein-Barr viral (EBV) DNA is nearly always detectable in African Burkitt's lymphoma (BL) but is infrequently found in the histologically indistinguishable American BL. We have derived a tumor cell line from a patient with American BL which produces EBV, and we have compared this virus isolate [JLP(c)] with African BL EBV. The American JLP(c) virus immortalizes human umbilical cord lymphocytes in vitro, and its DNA is indistinguishable from African BL EBV DNA by nucleic acid hybridization and preliminary restriction endonuclease cleavage analysis.

¹ To whom requests for reprints should be addressed, at National Cancer Institute, Building 10, Room 2B-50, Bethesda, Md. 20205.

Received 7/25/80. Accepted 4/23/81.