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Inhibition by Two Diphosphonates of Bone Lysis in Tumor-conditioned Media¹

Centre for the Study of Bone Diseases, Department of Medicine, University Hospital, Geneva, Switzerland

In order to test the effect of diphosphonates in inhibiting bone lysis induced by human tumors, neonatal mouse calvaria are cultured in sterile conditions in different media. Osteolysis is estimated by the amount of ⁴⁵Ca released from bone to medium, the mice being given injections of ⁴⁵Ca on their day of birth. An increased bone lysis is observed when calvaria are incubated in the same medium conditioned from cultured tumor fragments. This effect is significantly decreased when the mice have been treated with either ethanehydroxydiphosphonate or dichloromethylenediphosphonate. These experiments represent a first step in estimating the potential effects of different drugs on malignant osteolysis.

¹ Work supported by grants from the Swiss Foundation for Grants in Biology and Medicine, by the Swiss League Against Cancer, and by the Intermaritime Foundation.

² To whom requests for reprints should be addressed, at Clinique Médicale Thérapeutique, Hôpital Cantonal, 1211 Geneva 4, Switzerland.

Received 1/24/80. Accepted 5/ 4/81.

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