This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Iype, P. T. Articles by McMahon, J. B. Search for Related Content PubMed PubMed Citation Articles by Iype, P. T. Articles by McMahon, J. B.

Lack of Correlation between the Response to a Proliferation Inhibitor and Other Transformation Markers in a Mutant Liver Cell Line¹

Chemical Carcinogenesis Program, Frederick Cancer Research Center, Frederick, Maryland 21701

A rat liver factor, which has been found previously to inhibit proliferation of untransformed rat liver cell lines but not of transformed liver cell lines, did not inhibit proliferation of the chemically transformed rat liver cell line, W-8. Moreover, a temperature-sensitive mutant derived from W-8 (TS-223), which exhibits an untransformed phenotype at 39.5–41° and a transformed phenotype at 36°, was not affected by the liver factor at either temperature. Since the factor can be incubated at 41° for 4 days without loss of activity, it would seem that the regulation of cell proliferation is not necessarily linked with the expression of other markers of transformed cells.

¹ This work was supported by Contract NO1-CO-75380 with the National Cancer Institute, NIH, Bethesda, Md. 20205.

² To whom requests for reprints should be addressed.

Received 2/27/81. Accepted 6/ 2/81.