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Association of Specific Chromosome Abnormalities with Type of Acute Leukemia and with Patient Age¹

Section of Hematology, Department of Medicine, The University of Chicago Hospitals and Clinics, Chicago, Illinois 60637

Complete data regarding age, sex, karyotype, and French-American-British Cooperative Group classification were available for 239 unselected patients with acute nonlymphocytic leukemia. Of these, 128 were classified as having acute myeloblastic leukemia (M1 or M2); within the acute myeloblastic leukemia group, 83 (65%) of the patients were chromosomally abnormal. Except for 16 patients with a t(8;21), the percentage of patients with an abnormal karyotype increased with age, particularly above the age of 50 years. Besides the patients with t(8;21), there were 29 patients with loss of part or all of chromosomes 5 and/or 7, 11 patients with +8, and 27 patients with other abnormalities. Of 70 patients with acute myelomonocytic leukemia (M4), on the other hand, 28 (40%) were chromosomally abnormal, only three had loss of chromosomes 5 or 7, one was -7, +8, and four were +8, whereas 20 had other abnormalities. This difference may reflect different etiological factors in these two types of leukemia.

¹ This work was supported in part by a contract from the United States Department of Energy, DE-AC02-80EV10350; by Grants CA-16910, CA-23954, and CA-25568 from the National Cancer Institute, Department of Health and Human Services; and by The University of Chicago Cancer Research Foundation.

² To whom requests for reprints should be addressed, at The University of Chicago, Department of Medicine, Section of Hematology/Oncology, 950 East 59th Street, Box 420, Chicago, Ill. 60637.

Received 2/27/81. Accepted 6/ 8/81.

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