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Mammary Carcinogenesis in Rats Fed Different Amounts and Types of Fat¹

Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Rats fed 20% corn oil or lard showed increased 7,12-dimethylbenzanthracene-induced mammary tumorigenesis and slightly increased growth rate compared to rats fed 5% fat; 20% corn oil accelerated sexual maturation, but 20% lard did not. In contrast, diets high in beef fat (30%) depressed tumor induction by 7,12-dimethylbenzanthracene or N-fluorenylacetamide compared to a diet containing 15% vegetable oil; dietary lipotrope content had no effect on tumorigenesis. Further studies are needed of the effects of type and amount of dietary fat on mammary tumorigenesis in several model systems.

¹ Presented at the Workshop on Fat and Cancer, December 10 to 12, 1979, Bethesda, Md.

This study was supported in part by USPHS Contract NO1 CP33238 and Grant RO1-CA 25538 from the National Cancer Institute.

² To whom requests for reprints should be addressed, at: E18-615, M.I.T., Cambridge, Mass. 02139.