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Cholesterol Excretion and Colon Cancer¹

Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts 02118

Populations consuming diets high in fat and cholesterol exhibit a greater incidence of colon cancer than those consuming less fat and cholesterol. Lowering elevated serum cholesterol levels experimentally or clinically is associated with increased large-bowel tumorigenesis. Thus, cholesterol lost to the gut, either dietary or endogenously synthesized, appears to have a role in large-bowel cancer. Whether the effect(s) is mediated by increases in fecal bile acid excretion or some other mechanism is not clear.

¹ Presented at the Workshop on Fat and Cancer, December 10 to 12, 1979, Bethesda, Md. Supported in part by the National Large Bowel Cancer Project, National Cancer Institute Grant CA 16750.