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Differential Segregation Patterns of Human Chromosomes in Somatic Cell Hybrids Constructed with Human B-Lymphocytes and Human Melanoma Cells¹

Department of Medicine, Hematology/Oncology Division, University of California, San Diego, Veterans Administration Medical Center, La Jolla, California 92161 [M. C. G.], and Departments of Pathology and Surgery, Columbia University College of Physicians and Surgeons, New York, New York 10032 [S. F.]

Hybrids constructed with the murine fibroblasts IT22 and either human lymphoid cells or human melanoma cells retain the human chromosomes 1, 14, and 21 and lose the human chromosome 2. The human lymphocyte-mouse fibroblast hybrids preferentially retain the human chromosome 11, while the human melanoma-murine fibroblast hybrids preferentially retain the human chromosome 8 and lose the human chromosome X. These data suggest that the type of human parental cell used to construct human-rodent hybrids can influence the segregation of human chromosomes.

¹ Supported by NIH Grants Al 191989, CA 32609, CA 32619, and CA 29897 and by the Veterans' Administration.

Received 7/13/81. Accepted 7/ 1/82.