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Prostatic Hexosaminidase Activity in Patients with Benign Prostatic Hyperplasia and Prostatic Carcinoma¹

Departments of Pathology [G. B. W., J. P. M., T. G. P., E. A. B.], Biochemistry [G. B. W., T. G. P.], and biostatistics [E. L. B.], University of Alabama in Birmingham, Birmingham, Alabama 35294

Hexosaminidase activity in prostatic tissue has been compared in 15 patients with benign prostatic hyperplasia and 15 patients with prostatic carcinoma. The ratio of enzymatic activity for the two substrates tested (p-nitrophenyl-2-acetamido-2- deoxy-ß-D-glucopyranoside and p-nitrophenyl-2-acetamido-2- deoxy-ß-D-galactopyranoside) was not significantly different in the two groups of patients. The proportion of hexosaminidase represented by the B isozyme was not significantly different for the two groups of patients. Prostatic tissue hexosaminidase was greater (p = 0.0141) in carcinomatous prostates than in hyperplastic prostates.

¹ Supported by Grants CA 13148 and CA 31140 from the National Cancer Institute and by Grants PDT-126A and CD-141 from the American Cancer Society.

² To whom requests for reprints should be addressed.

Received 3/11/82. Accepted 6/24/82.