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Protection and Potentiation of Nitrogen Mustard Cytotoxicity by WR-2721¹

Section of Cancer Biology, Department of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110

The radioprotective agent WR-2721 was examined for its effects on modifying the cytotoxicity of HN2 against normal and tumor cells in the AKR mouse. Quantitation was carried out by the spleen colony assay for both normal hematopoietic stem cells and AKR leukemia cells. Protection from drug toxicity and normal cell cytotoxicity was noted. Potentiation of cytotoxicity to AKR leukemia was found.

¹ This work was supported by Grant CA 24960 from the National Cancer Institute, Department of Health and Human Services.

² To whom requests for reprints should be addressed at Section of Cancer Biology, Division of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park Blvd, Room 405, St. Louis, Mo. 63108.

Received 3/29/82. Accepted 7/26/82.

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