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Glucose Metabolism and the Percentage of Glucose Derived from Alanine: Response to Exogenous Glucose Infusion in Tumor-bearing and Non-Tumor-bearing Rats

Surgical Metabolism Section, Surgery Branch [J. M. A., M. E. B., C. M. G., M. F. B.], and Clinical and Diagnostic Trials Section, Biometry Branch [L. V. R.], National Cancer Institute, NIH, Bethesda, Maryland 20205

Glucose and alanine metabolism were investigated in non-tumor-bearing (NTB) and tumor-bearing (TB) male F344 rats after a 24-hr fast and during the infusion of either 0.9% NaCl solution or glucose at 0.67 or 2.35 mg per 100 g total body weight per min. During 0.9% NaCl solution infusion, the plasma glucose level was higher (98.2 ± 4.0 versus 85.8 ± 8.1 mg per dl; p < 0.05), the whole-blood lactate level was lower (5.8 ± 0.8 versus 8.3 ± 1.6 mg per dl; p < 0.05), the glucose turnover rate was lower (0.72 ± 0.04 versus 0.88 ± 0.13 mg per 100 g total body weight per min; p < 0.05), alanine turnover rate and the percentage of glucose derived from alanine was measured by [¹⁴C]alanine in the NTB and compared to the TB animals.

In response to glucose infusions, the whole-blood lactate level rose in both groups but remained lower (7.1 ± 0.9 versus 10.5 ± 2.4 mg per dl at 0.67 mg per 100 g total body weight per min, p < 0.05; 9.1 ± 1.1 versus 19.3 ± 5.5 mg per dl at 2.35 mg per 100 g total body weight per min, p < 0.05; NTB versus TB) in the NTB than in the TB animals. The endogenous production rate of glucose as measured by [³H]glucose displayed a similar response to exogenous substrate in the NTB and TB animals but required a higher plasma glucose concentration to effect a similar degree of suppression in the TB group. The alanine turnover rate rose to a similar level, and the percentage of glucose derived from alanine was similarly depressed in the NTB and TB animals at each glucose infusion rate.

¹ To whom requests for reprints should be addressed, at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, N. Y. 10021.

Received 3/ 4/81. Accepted 8/16/82.

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