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Reactivity of Serum-armed Xenogeneic Macrophages to Breast Cancer Antigens

Cancer Research Laboratory, Abbott-Northwestern Hospital, Minneapolis, Minnesota 55407

Sera from breast cancer patients contained cytophilic antibody which armed guinea pig peritoneal macrophages. These macrophages then exhibited specific adherence inhibition in the presence of tissue culture tumor antigens. These antigens were obtained from primary cultures of autologous or allogeneic breast cancer cells. Sera from control subjects for the most part did not induce macrophage adherence inhibition in the presence of these same antigens.

¹ William Lang, Jr., Cancer Research Fellow.

² To whom requests for reprints should be addressed, at Clinical Associate Professor of Surgery, University of Minnesota Medical School, 2545 Chicago Ave. S, Minneapolis, Minn. 55404.

Received 8/ 3/81. Accepted 8/25/82.